Analysis of factors that control transcriptional fidelity and chromatin structure

Abstract: Nucleosomes are barriers for transcription. To help to alleviate these barriers, a class of factors called histone chaperones modulates histone-DNA interactions. Our work has focused on set of three histone chaperones that are essential for viability and that are conserved from yeast to humans. Our studies, using S. cerevisiae as a model system, have shown that these three factors, Spt6, Spn1, and FACT, are broadly required for the fidelity of transcription and the integrity of chromatin structure. While all three histone chaperones are vital for growth, we have found unexpected connections between their functions that suggest that they interact in a network that is critical for their functions in transcription, as well as other chromatin-templated functions including DNA replication and genome stability.

biochemistrycancer biologychemical biologycell biologydevelopmental biologydrug discoveryevolutiongeneticsimmunologymolecular biologymicrobiologyneuroscienceplant sciencessystems biologybiotechnologybiological techniquesbiophysics

Audience: researchers in the discipline

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Colloquium zooming Molecular & Cellular Biology LUMS

Series comments: Zooming Molecular & Cellular Biology Colloquium was initiated on July 28th, 2020 by the Biology department at Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS). The series follows through various topics which come under the ambit of Molecular and Cellular Biology and we’ve had the pleasure and honor of hosting some of the most knowledgeable scientists from around the globe. Organizers can be reached out at 24100162@lums.edu.pk or 24100001@lums.edu.pk for the Zoom link of individual talks. All lectures are LIVE streamed on SBASSE's official Facebook page.